Associations between daily aspirin use and cancer risk across strata of major cancer risk factors in two large U.S. cohorts.

ABSTRACT:

Purpose

Daily aspirin use has been shown to reduce risk of colorectal, and possibly other, cancers, but it is unknown if these benefits are consistent across subgroups of people with differing cancer risk factors. We investigated whether age, body mass index (BMI), smoking status, physical inactivity, and family history of cancer modify the effect of daily aspirin use on colorectal, ovarian, breast, endometrial and aggressive prostate cancer risk.

Methods

We pooled 423,495 individuals from two prospective, U.S.-based studies: the NIH-AARP Diet and Health Study (1995-2011) and the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial (1993-2009). Using Cox proportional hazards regression, we examined associations between daily aspirin use (≥ 5 days/week) and risk of

SUBMITTER: Hurwitz LM 

PROVIDER: S-EPMC7855934 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature