Comparing neural correlates of conditioned inhibition between children with and without anxiety disorders - A preliminary study.

ABSTRACT: Cognitive-behavioral therapy (CBT), a first-line treatment for pediatric anxiety disorders, is based on principles of threat learning and extinction. However, CBT does not work sufficiently for up to 40% of clinically anxious youth. The neural and behavioral correlates of conditioned inhibition might provide promising targets for attempts to improve CBT response. During conditioned inhibition, threat and safety cues appear together, forming a safety compound. Here, we test whether this safety compound elicits a reduced fear response compared to pairing the threat cue with a novel cue (novel compound). The current pilot study compares behavioral, physiological, and neural correlates of conditioned inhibition between children with (n = 17, M_age = 13.09, SD_age = 3.05) an

SUBMITTER: Harrewijn A 

PROVIDER: S-EPMC7855938 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature