Night-to-night variability of sleep electroencephalography-based brain age measurements.

ABSTRACT:

Objective

Brain Age Index (BAI), calculated from sleep electroencephalography (EEG), has been proposed as a biomarker of brain health. This study quantifies night-to-night variability of BAI and establishes probability thresholds for inferring underlying brain pathology based on a patient's BAI.

Methods

86 patients with multiple nights of consecutive EEG recordings were selected from Epilepsy Monitoring Unit patients whose EEGs reported as within normal limits. While EEGs with epileptiform activity were excluded, the majority of patients included in the study had a diagnosis of chronic epilepsy. BAI was calculated for each 12-hour segment of patient data using a previously established algorithm, and the night-to-night variability in BAI was measured.

Results

The withi

SUBMITTER: Hogan J 

PROVIDER: S-EPMC7855943 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature