Diagnostic Accuracy of Amyloid versus ¹⁸ F-Fluorodeoxyglucose Positron Emission Tomography in Autopsy-Confirmed Dementia.

ABSTRACT:

Objective

The purpose of this study was to compare the diagnostic accuracy of antemortem ¹¹ C-Pittsburgh compound B (PIB) and ¹⁸ F-fluorodeoxyglucose (FDG) positron emission tomography (PET) versus autopsy diagnosis in a heterogenous sample of patients.

Methods

One hundred one participants underwent PIB and FDG PET during life and neuropathological assessment. PET scans were visually interpreted by 3 raters blinded to clinical information. PIB PET was rated as positive or negative for cortical retention, whereas FDG scans were read as showing an Alzheimer disease (AD) or non-AD pattern. Neuropathological diagnoses were assigned using research criteria. Majority visual reads were compared to intermediate-high AD neuropathological change (ADNC).

Result

SUBMITTER: Lesman-Segev OH 

PROVIDER: S-EPMC7856004 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature