Bile acids profile, histopathological indices and genetic variants for non-alcoholic fatty liver disease progression.

ABSTRACT:

Objective

Metabolomic studies suggest plasma levels of bile acids (BAs) are elevated amongst subjects with non-alcoholic fatty liver disease (NAFLD) compared to healthy controls. However, it remains unclear whether or not specific BAs are associated with the clinically relevant transition from nonalcoholic fatty liver (i.e. simple steatosis) to non-alcoholic steatohepatitis (NASH), or enhanced progression of hepatic fibrosis, or genetic determinants of NAFLD/NASH.

Methods

Among sequential subjects (n=102) undergoing diagnostic liver biopsy, we examined the associations of a broad panel of BAs with distinct histopathological features of NAFLD, the presence of NASH, and their associations with genetic variants linked to NAFLD and NASH.

Results

Plasma BA alterations were

SUBMITTER: Nimer N 

PROVIDER: S-EPMC7856026 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature