Dynamically tunable light responsive silk-elastin-like proteins.

ABSTRACT: Dynamically tunable biomaterials are of particular interest in the field of biomedical engineering because of the potential utility for shape-change materials, drug and cell delivery and tissue regeneration. Stimuli-responsive proteins formed into hydrogels are potential candidates for such systems, due to the genetic tailorability and control over structure-function relationships. Here we report the synthesis of genetically engineered Silk-Elastin-Like Protein (SELP) photoresponsive hydrogels. Polymerization of the SELPs and monomeric adenosylcobalamin (AdoB₁₂)-dependent photoreceptor C-terminal adenosylcobalamin binding domain (CarH_C) was achieved using genetically encoded SpyTag-SpyCatcher peptide-protein pairs under mild physiological conditions. The hydrogels exh

SUBMITTER: Narayan OP 

PROVIDER: S-EPMC7856074 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature