The Borrelia burgdorferi infection critical BBK13 protein forms large oligomers in the spirochete membrane.

ABSTRACT: Borrelia burgdorferi is the causative agent of Lyme disease, the leading tick-borne illness in the United States. However, due to, in part, to the significant number of proteins of unknown function encoded across the complex fragmented genome, the molecular mechanisms of B. burgdorferi infection remain largely undefined. Previous work identified the virulence determinant gene, bbk13, which is critical for B. burgdorferi's ability to establish a productive disseminated infection. BBK13 is an immunogenic, non-surface exposed protein of unknown function predicted to harbor an N-terminal transmembrane domain and annotated as a member of the SIMPL domain protein superfamily (PF04402). In eukaryotes, SIMPL domain proteins have been shown to contribute to NF-kappa-B signaling but have no known fu

SUBMITTER: Kuhn HW 

PROVIDER: S-EPMC7856088 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature