Myocardial Gene Expression Signatures in Human Heart Failure With Preserved Ejection Fraction.

ABSTRACT:

Background

Heart failure (HF) with preserved ejection fraction (HFpEF) constitutes half of all HF but lacks effective therapy. Understanding of its myocardial biology remains limited because of a paucity of heart tissue molecular analysis.

Methods

We performed RNA sequencing on right ventricular septal endomyocardial biopsies prospectively obtained from patients meeting consensus criteria for HFpEF (n=41) contrasted with right ventricular septal tissue from patients with HF with reduced ejection fraction (HFrEF, n=30) and donor controls (n=24). Principal component analysis and hierarchical clustering tested for transcriptomic distinctiveness between groups, effect of comorbidities, and differential gene expression with pathway enrichment contrasted HF groups and donor contro

SUBMITTER: Hahn VS 

PROVIDER: S-EPMC7856095 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature