Prophylactic Negative Pressure Wound Therapy After Laparotomy for Gynecologic Surgery: A Randomized Controlled Trial.

ABSTRACT:

Objective

To estimate the effectiveness of prophylactic negative pressure wound therapy in patients undergoing laparotomy for gynecologic surgery.

Methods

We conducted a randomized controlled trial. Eligible, consenting patients, regardless of body mass index (BMI), who were undergoing laparotomy for presumed gynecologic malignancy were randomly allocated to standard gauze or negative pressure wound therapy. Patients with BMIs of 40 or greater and benign disease also were eligible. Randomization, stratified by BMI, occurred after skin closure. The primary outcome was wound complication within 30 (±5) days of surgery. A sample size of 343 per group (N=686) was planned.

Results

From March 1, 2016, to August 20, 2019, we identified 663 potential patients; 289 were random

SUBMITTER: Leitao MM 

PROVIDER: S-EPMC7856105 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature