Enhanced weight and fat loss from long-term intermittent fasting in obesity-prone, low-fitness rats.

ABSTRACT:

Background

Intermittent fasting (IF) strategies have emerged as viable alternatives to traditional calorie-restricted diets. A key predictor of metabolic health and response to diet is cardiometabolic fitness, including intrinsic aerobic capacity. In a contrasting rat model of aerobic capacity-high- and low-capacity runners (HCR, LCR)-we found that the lean and physically active HCR were also more responsive to a standard calorie-restricted diet. Here, we assessed the ability of IF to induce weight loss on a background of high and low aerobic fitness accompanied by different levels of daily physical activity.

Methods

Female HCR and LCR (8 per line) were subjected to IF (alternate-day fasting) for 14 weeks. Outcomes included changes in body weight, fat and lean mass, daily ph

SUBMITTER: Smyers ME 

PROVIDER: S-EPMC7856160 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature