Diet-derived fruit and vegetable metabolites show sex-specific inverse relationships to osteoporosis status.

ABSTRACT:

Background

The impact of nutrition on the metabolic profile of osteoporosis (OS) is unknown.

Objective

Identify biochemical factors driving the association of fruit and vegetable (FV) intakes with OS prevalence using an untargeted metabolomics approach.

Design

Cross-sectional dietary, anthropometric and plasma metabolite data were examined from the Boston Puerto Rican Osteoporosis Study, n = 600 (46-79 yr).

Methods

Bone mineral density was assessed by DXA. OS was defined by clinical standards. A culturally adapted FFQ assessed usual dietary intake. Principal components analysis (PCA) of 42 FV items created 6 factors. Metabolomic profiles derived from plasma samples were assessed on a commercial platform. Differences in levels of 525 plasma metabolites between d

SUBMITTER: Mangano KM 

PROVIDER: S-EPMC7856195 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature