Sorting nexin 5 mediates virus-induced autophagy and immunity.

ABSTRACT: Autophagy, a process of degradation that occurs via the lysosomal pathway, has an essential role in multiple aspects of immunity, including immune system development, regulation of innate and adaptive immune and inflammatory responses, selective degradation of intracellular microorganisms, and host protection against infectious diseases^1,2. Autophagy is known to be induced by stimuli such as nutrient deprivation and suppression of mTOR, but little is known about how autophagosomal biogenesis is initiated in mammalian cells in response to viral infection. Here, using genome-wide short interfering RNA screens, we find that the endosomal protein sorting nexin 5 (SNX5)^3,4 is essential for virus-induced, but not for basal, stress- or endosome-induced, autophagy. We show th

SUBMITTER: Dong X 

PROVIDER: S-EPMC7856200 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature