Outcomes of Severe Seronegative Hepatitis-associated Aplastic Anemia: A Pediatric Case Series.

ABSTRACT:

Objectives

Hepatitis-associated aplastic anemia (HAAA) is a potentially life-threatening diagnosis without clear treatment guidelines. The goal of the study was to characterize the presentation, evaluation, histopathology, and outcomes of therapy in children with HAAA to guide future research and to develop standardized care guidelines for this rare disease.

Methods

Retrospective chart review of 4 patients with HAAA who presented to Children's Hospital Colorado between 2016 and 2019 was conducted. Patient presentation, evaluation, bone marrow and liver pathology, interventions, and clinical course were collected. Immunohistochemistry of liver biopsies was performed.

Results

We treated 4 patients with HAAA without liver failure. All had evidence of systemic hyperinflam

SUBMITTER: Kemme S 

PROVIDER: S-EPMC7856235 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature