Association of early hypotension in pediatric sepsis with development of new or persistent acute kidney injury.

ABSTRACT:

Objective

To determine how hypotension in the first 48 h of sepsis management impacts acute kidney injury (AKI) development and persistence.

Study design

Retrospective study of patients > 1 month to < 20 years old with sepsis in a pediatric ICU between November 2012 and January 2015 (n = 217). All systolic blood pressure (SBP) data documented within 48 h after sepsis recognition were collected and converted to percentiles for age, sex, and height. Time below SBP percentiles and below pediatric advanced life support (PALS) targets was calculated by summing elapsed time under SBP thresholds during the first 48 h. The primary outcome was new or persistent AKI, defined as stage 2 or 3 AKI present between sepsis day 3-7 using Kidney Disease: Improving Global Outcomes creatinine d

SUBMITTER: Fitzgerald JC 

PROVIDER: S-EPMC7856266 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature