Association of biomarkers of exposure to metals and metalloids with maternal hormones in pregnant women from Puerto Rico.

ABSTRACT:

Background

Metal(loid)s have been associated to adverse birth outcomes in experimental and epidemiological studies, but the underlying mechanism(s) are not well understood. Endocrine disruption may be a mechanism by which the metal(loid)s impact birth outcomes.

Methods

Pregnant women were recruited through the Puerto Rico Testsite for Exploring Contamination Threats (PROTECT). Urine, blood, demographic and pregnancy-related data were collected at recruitment and subsequent visits. Sixteen metal(loid)s were analyzed in urine and blood samples, while nine maternal hormones (corticotropin-releasing hormone (CRH), sex-hormone binding globulin (SHBG), estriol (E3), progesterone, testosterone, thyroid-stimulating hormone (TSH), total triiodothyronine (T3), total thyroxine (T4), an

SUBMITTER: Rivera-Nunez Z 

PROVIDER: S-EPMC7856269 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature