Ontology highlight
ABSTRACT:
SUBMITTER: Qiu X
PROVIDER: S-EPMC7856276 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Qiu Xuefeng X Lee Benjamin Li-Ping BL Wong Sze Yue SY Ding Xili X Xu Kang K Xu Kang K Zhao Wen W Wang Dong D Sochol Ryan R Dong Nianguo N Li Song S
Biomaterials 20201201
The replacement of small-diameter arteries remains an unmet clinical need. Here we investigated the cellular remodeling of fibrotic conduits as vascular grafts. The formation of fibrotic conduit around subcutaneously implanted mandrels involved not only fibroblasts but also the trans-differentiation of inflammatory cells such as macrophages into fibroblastic cells, as shown by genetic lineage tracing. When fibrotic conduits were implanted as vascular grafts, the patency was low, and many fibroti ...[more]