Functional and structural characterization of Hyp730, a highly conserved and dormancy-specific hypothetical membrane protein.

ABSTRACT: Membrane proteins represent major drug targets, and the ability to determine their functions, structures, and conformational changes will significantly advance mechanistic approaches to both biotechnology and bioremediation, as well as the fight against pathogenic bacteria. A pertinent example is Mycobacterium tuberculosis (H37Rv), which contains ~4000 protein-coding genes, with almost a thousand having been categorized as 'membrane protein', and a few of which (~1%) have been functionally characterized and structurally modeled. However, the functions and structures of most membrane proteins that are sparsely, or only transiently, expressed, but essential in small phenotypic subpopulations or under stress conditions such as persistence or dormancy, remain unknown. Our deep quantitative pro

SUBMITTER: Fannin S 

PROVIDER: S-EPMC7856521 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature