Effect of Early Balanced Crystalloids Before ICU Admission on Sepsis Outcomes.

ABSTRACT:

Background

Studies suggest that using balanced crystalloids (lactated Ringer's solution or Plasma-Lyte A) rather than saline (0.9% sodium chloride) may improve outcomes for patients with sepsis in the ED and ICU.

Research question

What is the relative impact on sepsis outcomes of fluid composition during early resuscitation in the ED vs after ICU admission?

Study design and methods

We performed a secondary analysis of the Isotonic Solutions and Major Adverse Renal Events Trial (SMART) data set, examining medical ICU patients with a diagnosis of sepsis (n = 1,641). SMART was a cluster-crossover trial comparing balanced crystalloids vs saline among critically ill adults. During the first 7 months of SMART, fluid choice was controlled only in the ICU ("ICU-only period").

SUBMITTER: Jackson KE 

PROVIDER: S-EPMC7856532 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature