Vascular Pruning on CT and Interstitial Lung Abnormalities in the Framingham Heart Study.

ABSTRACT:

Background

Pulmonary vascular disease is associated with poor outcomes in individuals affected by interstitial lung disease. The pulmonary vessels can be quantified with noninvasive imaging, but whether radiographic indicators of vasculopathy are associated with early interstitial changes is not known.

Research question

Are pulmonary vascular volumes, quantified from CT scans, associated with interstitial lung abnormalities (ILA) in a community-based sample with a low burden of lung disease?

Study design and methods

In 2,386 participants of the Framingham Heart Study, we used CT imaging to calculate pulmonary vascular volumes, including the small vessel fraction (a surrogate of vascular pruning). We constructed multivariable logistic regression models to investigate a

SUBMITTER: Synn AJ 

PROVIDER: S-EPMC7856535 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature