Microarray analysis reveals an inflammatory transcriptomic signature in peripheral blood for sciatica.

ABSTRACT:

Background

Although the pathology of sciatica has been studied extensively, the transcriptional changes in the peripheral blood caused by sciatica have not been characterized. This study aimed to characterize the peripheral blood transcriptomic signature for sciatica.

Methods

We used a microarray to identify differentially expressed genes in the peripheral blood of patients with sciatica compared with that of healthy controls, performed a functional analysis to reveal the peripheral blood transcriptomic signature for sciatica, and conducted a network analysis to identify key genes that contribute to the observed transcriptional changes. The expression levels of these key genes were assessed by qRT-PCR.

Results

We found that 153 genes were differentially expressed in t

SUBMITTER: Wang Y 

PROVIDER: S-EPMC7856817 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature