Changes in gut microbiota composition and diversity associated with post-cholecystectomy diarrhea.

ABSTRACT:

Background

Post-cholecystectomy diarrhea (PCD) frequently occurs in patients following gallbladder removal. PCD is part of the post-cholecystectomy (PC) syndrome, and is difficult to treat. After cholecystectomy, bile enters the duodenum directly, independent of the timing of meals. The interaction between the bile acids and the intestinal microbes is changed. Therefore, the occurrence of PCD may be related to the change in microbiota. However, little is known about the relationship between the gut microbiota and PCD.

Aim

To better understand the role of the gut microbiota in PCD patients.

Methods

Fecal DNA was isolated. The diversity and profiles of the gut microbiota were analyzed by performing high-throughput 16S rRNA gene sequencing. The gut microbiota were charac

SUBMITTER: Li YD 

PROVIDER: S-EPMC7856843 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature