¹⁵ N-carnitine, a novel endogenous hyperpolarized MRI probe with long signal lifetime.

ABSTRACT:

Purpose

The purpose of this study was to investigate hyperpolarization and in vivo imaging of [¹⁵ N]carnitine, a novel endogenous MRI probe with long signal lifetime.

Methods

L-[¹⁵ N]carnitine-d₉ was hyperpolarized by the method of dynamic nuclear polarization followed by rapid dissolution. The T₁ signal lifetimes were estimated in aqueous solution and in vivo following intravenous injection in rats, using a custom-built dual-tuned ¹⁵ N/¹ H RF coil at 4.7 T. ¹⁵ N chemical shift imaging and ¹⁵ N fast spin-echo images of rat abdomen were acquired 3 minutes after [¹⁵ N]carnitine injection.

Results

Estimated T₁ times of [¹⁵ N]carnitine at 4.7 T were 210

SUBMITTER: von Morze C 

PROVIDER: S-EPMC7856872 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature