Genetic Ablation of G Protein-Gated Inwardly Rectifying K⁺ Channels Prevents Training-Induced Sinus Bradycardia.

ABSTRACT: Background: Endurance athletes are prone to bradyarrhythmias, which in the long-term may underscore the increased incidence of pacemaker implantation reported in this population. Our previous work in rodent models has shown training-induced sinus bradycardia to be due to microRNA (miR)-mediated transcriptional remodeling of the HCN4 channel, leading to a reduction of the "funny" (I _f) current in the sinoatrial node (SAN). Objective: To test if genetic ablation of G-protein-gated inwardly rectifying potassium channel, also known as I _KACh channels prevents sinus bradycardia induced by intensive exercise training in mice. Methods: Control wild-type (WT) and mice lacking GIRK4 (Girk4 ^-/-), an integral subunit of

SUBMITTER: Bidaud I 

PROVIDER: S-EPMC7857143 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature