Selective Decay of Intact HIV-1 Proviral DNA on Antiretroviral Therapy.

ABSTRACT:

Background

HIV-1 proviruses persist in people on antiretroviral therapy (ART) but most are defective and do not constitute a replication-competent reservoir. The decay of infected cells carrying intact compared with defective HIV-1 proviruses has not been well defined in people on ART.

Methods

We separately quantified intact and defective proviruses, residual plasma viremia, and markers of inflammation and activation in people on long-term ART.

Results

Among 40 participants tested longitudinally from a median of 7.1 years to 12 years after ART initiation, intact provirus levels declined significantly over time (median half-life, 7.1 years; 95% confidence interval [CI], 3.9-18), whereas defective provirus levels did not decrease. The median half-life of total HIV-1 DNA

SUBMITTER: Gandhi RT 

PROVIDER: S-EPMC7857155 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature