Glial restricted precursor cells in central nervous system disorders: Current applications and future perspectives.

ABSTRACT: The crosstalk between glial cells and neurons represents an exceptional feature for maintaining the normal function of the central nervous system (CNS). Increasing evidence has revealed the importance of glial progenitor cells in adult neurogenesis, reestablishment of cellular pools, neuroregeneration, and axonal (re)myelination. Several types of glial progenitors have been described, as well as their potentialities for recovering the CNS from certain traumas or pathologies. Among these precursors, glial-restricted precursor cells (GRPs) are considered the earliest glial progenitors and exhibit tripotency for both Type I/II astrocytes and oligodendrocytes. GRPs have been derived from embryos and embryonic stem cells in animal models and have maintained their capacity for self-renewal. Desp

SUBMITTER: Martins-Macedo J 

PROVIDER: S-EPMC7857417 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature