Protein Modification Characteristics of the Malaria Parasite Plasmodium falciparum and the Infected Erythrocytes.

ABSTRACT: Malaria elimination is still pending on the development of novel tools that rely on a deep understanding of parasite biology. Proteins of all living cells undergo myriad posttranslational modifications (PTMs) that are critical to multifarious life processes. An extensive proteome-wide dissection revealed a fine PTM map of most proteins in both Plasmodium falciparum, the causative agent of severe malaria, and the infected red blood cells. More than two-thirds of proteins of the parasite and its host cell underwent extensive and dynamic modification throughout the erythrocytic developmental stage. PTMs critically modulate the virulence factors involved in the host-parasite interaction and pathogenesis. Furthermore, P. falciparum stabilized the supporting proteins of erythrocyte origin by sel

SUBMITTER: Wang J 

PROVIDER: S-EPMC7857547 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature