Individual adherence to mass drug administration in neglected tropical disease control: A probability model conditional on past behaviour.

ABSTRACT: We present a general framework which describes the systematic (binary) scenario of individuals either taking treatment or not for any reason, over the course of mass drug administration (MDA)-which we refer to as 'adherence' and 'non-adherence'. The probability models developed can be informed by observed adherence behaviour as well as employed to explore how different patterns influence the impact of MDA programmes, by the use of mathematical models of transmission and control. We demonstrate the interpretative value of the developed probability model employing a dataset collected in the TUMIKIA project, a randomised trial of deworming strategies to control soil-transmitted helminths (STH) by MDA conducted in coastal Kenya. We stratify our analysis by age and sex, although the framework w

SUBMITTER: Hardwick RJ 

PROVIDER: S-EPMC7857569 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature