Ontology highlight
ABSTRACT:
SUBMITTER: Fukuda T
PROVIDER: S-EPMC7857730 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
Fukuda Tomoyuki T Sofyantoro Fajar F Tai Yen Teng YT Chia Kim Hou KH Matsuda Takato T Murase Takaaki T Morozumi Yuichi Y Tatebe Hisashi H Kanki Tomotake T Shiozaki Kazuhiro K
eLife 20210203
Mammalian target of rapamycin complex 1 (TORC1) is controlled by the GATOR complex composed of the GATOR1 subcomplex and its inhibitor, the GATOR2 subcomplex, sensitive to amino acid starvation. Previously, we identified fission yeast GATOR1 that prevents deregulated activation of TORC1 (Chia et al., 2017). Here, we report identification and characterization of GATOR2 in fission yeast. Unexpectedly, the GATOR2 subunit Sea3, an ortholog of mammalian WDR59, is physically and functionally proximal ...[more]