Hydrogen sulfide, oxygen, and calcium regulation in developing human airway smooth muscle.
Ontology highlight
ABSTRACT: Preterm infants can develop airway hyperreactivity and impaired bronchodilation following supplemental O2 (hyperoxia) in early life, making it important to understand mechanisms of hyperoxia effects. Endogenous hydrogen sulfide (H2 S) has anti-inflammatory and vasodilatory effects with oxidative stress. There is little understanding of H2 S signaling in developing airways. We hypothesized that the endogenous H2 S system is detrimentally influenced by O2 and conversely H2 S signaling pathways can be leveraged to attenuate deleterious effects of O2 . Using human fetal airway smooth muscle (fASM) cells, we investigated baseline expression of endogenous H2 S machinery, and effects of exogenous H2
SUBMITTER: Bartman CM
PROVIDER: S-EPMC7857779 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
ACCESS DATA
