Effects of a medium cut-off (Theranova^®) dialyser on haemodialysis patients: a prospective, cross-over study.

ABSTRACT:

Background

Despite significant advances in haemodialysis (HD) in recent decades, current dialysis techniques are limited by inadequate removal of uraemic solutes such as middle molecules and protein-bound uraemic toxins. Novel medium cut-off (MCO) membrane or 'expanded haemodialysis' (HDx) provides diffusive removal of conventional and large middle molecular weight uraemic toxins, with marginal albumin leak.

Methods

This prospective, open-label, controlled, cross-over pilot study compared HDx (novel MCO membrane Theranova^® 400) and conventional HD in 20 prevalent HD patients. Biochemical, dialysis adequacy and safety measures (adverse events, infections and hospitalization frequency) were recorded. Ten patients underwent conventional HD high-flux dialyser and 10 p

SUBMITTER: Cozzolino M 

PROVIDER: S-EPMC7857781 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature