Serum uromodulin and decline of kidney function in older participants of the population-based KORA F4/FF4 study.

ABSTRACT:

Background

Uromodulin, a tissue-specific tubular glycoprotein, has recently emerged as a promising biomarker for kidney function and tubular integrity. However, the association of serum uromodulin (sUmod) with renal function decline is still unknown in an older general population.

Methods

We analysed the association of sUmod with the estimated glomerular filtration rate (eGFR) and albuminuria in 1075 participants of the population-based Cooperative Health Research in the Region of Augsburg (KORA) F4 study, ages 62-81 years, at baseline and prospectively after a mean follow-up time of 6.5 years (n = 605) using logistic and linear regression models as well as receiver operating characteristics (ROC) analyses.

Results

Cross-sectionally, sUmod was positively associ

SUBMITTER: Then C 

PROVIDER: S-EPMC7857794 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature