Measurement of renal functional response using iohexol clearance-a study of different outpatient procedures.

ABSTRACT:

Background

Glomerular filtration rate (GFR) increases after a heavy protein load; an increase termed renal functional response (RFR). Decreased RFR could be a marker of early kidney damage, but published methods are cumbersome in the outpatient setting. The present study investigates the use of iohexol clearance to measure RFR in outpatients using both one- and two-sample methods.

Methods

Fourteen healthy volunteers with a mean ± SD age of 42 ± 12 years were included (six males and eight females). GFR was measured using plasma iohexol clearance with one- and two-sample methodologies. Four measurements in each individual were performed: one baseline test and three protein loading tests containing 80 g protein (commercially available protein supplementations from Myo Nutrition

SUBMITTER: Lillas BS 

PROVIDER: S-EPMC7857819 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature