Poor allograft outcome in Indian patients with post-transplant C3 glomerulopathy.

ABSTRACT:

Background

Complement 3 glomerulopathy (C3G) results from dysfunction of the alternative complement pathway (ACP). No data are available on post-transplant C3G in South Asia.

Methods

In this study, renal allograft biopsies of C3G patients performed from 2012 to 2017 were analysed for ACP functional assay (APFA), serum complement levels, complement factor H (CFH), complement factor B (CFB) and autoantibodies to CFH and CFB. Limited genetic screening for CFH/CFHR5 genes was carried out. All study patients were also followed up.

Results

A total of 21 cases of C3G were included, of which 11 had native C3G disease (that is, recurrent C3G). Of these 11 recurrent cases, 7 presented with allograft dysfunction and 4 with proteinuria and renal dysfunction. Early p

SUBMITTER: Kumar A 

PROVIDER: S-EPMC7857824 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature