Unknown

Dataset Information

0

Design and Synthesis of 4-O-Podophyllotoxin Sulfamate Derivatives as Potential Cytotoxic Agents.

ABSTRACT: 4-O-Podophyllotoxin sulfamate derivatives were prepared using the natural lignan podophyllotoxin. The prepared compounds were afforded by reacting O-sulfonyl chloride podophyllotoxin with ammonia or aminoaryl/heteroaryl motif. Biological evaluation was performed in human breast cancer (MCF7), ovarian cancer (A2780), colon adenocarcinoma (HT29), and normal lung fibroblast (MRC5) cell lines. Compound 3 exhibited potent inhibitory activity and good selectivity margin. Compounds 2, 3, and 7 exerted apoptotic effect in MCF7 cells in a dose-dependent manner. The cytotoxicity of the verified compounds was inferior to that of podophyllotoxin.

SUBMITTER: Bader A 

PROVIDER: S-EPMC7857870 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature

Json Xml
altmetric image

Publications

Design and Synthesis of 4-O-Podophyllotoxin Sulfamate Derivatives as Potential Cytotoxic Agents.

Bader Ammar A   Bkhaitan Majdi M MM   Abdalla Ashraf N AN   Abdallah Qasem M A QMA   Ali Hamed I HI   Sabbah Dima A DA   Albadawi Ghadeer G   Abushaikha Ghassan M GM  

Evidence-based complementary and alternative medicine : eCAM 20210125

4-O-Podophyllotoxin sulfamate derivatives were prepared using the natural lignan podophyllotoxin. The prepared compounds were afforded by reacting O-sulfonyl chloride podophyllotoxin with ammonia or aminoaryl/heteroaryl motif. Biological evaluation was performed in human breast cancer (MCF7), ovarian cancer (A2780), colon adenocarcinoma (HT29), and normal lung fibroblast (MRC5) cell lines. Compound <b>3</b> exhibited potent inhibitory activity and good selectivity margin. Compounds <b>2</b>, <b>  ...[more]

Similar Datasets

Unknown Design, Synthesis, and Biological Evaluation of Novel Biotinylated Podophyllotoxin Derivatives as Potential Antitumor Agents.
| S-EPMC6596340 | biostudies-literature
Unknown Madecassic Acid Derivatives as Potential Anticancer Agents: Synthesis and Cytotoxic Evaluation.
| S-EPMC7428852 | biostudies-literature
Unknown Design and Synthesis of Pyrrolo[2,1-a]Isoquinoline-Based Derivatives as New Cytotoxic Agents.
| S-EPMC5316252 | biostudies-literature
Unknown Design and Synthesis of Benzimidazole-Chalcone Derivatives as Potential Anticancer Agents.
| S-EPMC6767017 | biostudies-literature
Unknown Design, synthesis and evaluation of carbazole derivatives as potential antimicrobial agents.
| S-EPMC7801072 | biostudies-literature
Unknown Design, synthesis and biological evaluation of novel benzodioxole derivatives as COX inhibitors and cytotoxic agents.
| S-EPMC7487730 | biostudies-literature
Unknown Design and synthesis of new 7-(N-substituted-methyl)-camptothecin derivatives as potent cytotoxic agents.
| S-EPMC4130764 | biostudies-literature
Unknown Design, synthesis and bioactivity investigation of tetrandrine derivatives as potential anti-cancer agents.
| S-EPMC6072089 | biostudies-other
Unknown Synthesis and Biological Evaluation of 4β-N-Acetylamino Substituted Podophyllotoxin Derivatives as Novel Anticancer Agents.
| S-EPMC6491884 | biostudies-literature
Unknown Design, Synthesis and Evaluation of Hesperetin Derivatives as Potential Multifunctional Anti-Alzheimer Agents.
| S-EPMC6152180 | biostudies-literature