Immune Cell Landscape in Gastric Cancer.

ABSTRACT:

Background

The tumor-infiltrating immune cells are closely associated with the prognosis of gastric cancer (GC). This article is aimed at determining the composition change of immune cells and immune regulatory factors in GC and normal tissues, depicting their prognosis value in GC, and revealing the relationship between them and GC clinical parameters.

Methods

We used CIBERSORT to calculate the proportion of 22 immune cells in the GC or normal tissues; a t-test was applied to assess the expression difference of immune cells and immune regulatory factors in normal and GC tissues. The relationship of the immune cells, immune regulatory factors, and GC patients' clinical characteristics was assessed by univariate analysis.

Results

In this study, we found that the

SUBMITTER: Yang Y 

PROVIDER: S-EPMC7857889 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature