Discovery of novel DNA methylation biomarkers for non-invasive sporadic breast cancer detection in the Latino population.

ABSTRACT: Human diversity is one of the main pitfalls in the development of robust worldwide biomarkers in oncology. Epigenetic variability across human populations is associated with different genetic backgrounds, as well as variable lifestyles and environmental exposures, each of which should be investigated. To identify potential non-invasive biomarkers of sporadic breast cancer in the Uruguayan population, we studied genome-wide DNA methylation using Illumina methylation arrays in leukocytes of 22 women with sporadic breast cancer and 10 healthy women in a case-control study. We described a panel of 38 differentially methylated CpG positions that was able to cluster breast cancer patients (BCP) and controls, and that also recapitulated methylation differences in 12 primary breast tumors and thei

SUBMITTER: Cappetta M 

PROVIDER: S-EPMC7858097 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature