Molecular genomic features associated with in vitro response of the NCI-60 cancer cell line panel to natural products.

ABSTRACT: Natural products remain a significant source of anticancer chemotherapeutics. The search for targeted drugs for cancer treatment includes consideration of natural products, which may provide new opportunities for antitumor cytotoxicity as single agents or in combination therapy. We examined the association of molecular genomic features in the well-characterized NCI-60 cancer cell line panel with in vitro response to treatment with 1302 small molecules which included natural products, semisynthetic natural product derivatives, and synthetic compounds based on a natural product pharmacophore from the Developmental Therapeutics Program of the US National Cancer Institute's database. These compounds were obtained from a variety of plant, marine, and microbial species. Molecular information uti

SUBMITTER: Krushkal J 

PROVIDER: S-EPMC7858122 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature