Influence of labor on direct and indirect determinants of placental 11beta-hydroxysteroid dehydrogenase activity.

ABSTRACT:

Purpose

Labor is a complex process involving multiple para-, auto- and endocrine cascades. The interaction of cortisol, corticotropin-releasing hormone (CRH) and progesterone is essential. The action of cortisol on the human feto-placental unit is regulated by 11beta-hydroxysteroid dehydrogenase type 2 (11β-HSD2/HSD11B2) that converts cortisol into inactive cortisone. The majority of studies on the assessment of placental 11β-HSD2 function determined indirect activity parameters. It remains elusive if indirect measurements correlate with enzymatic function and if these parameters are affected by potential confounders (e.g., mode of delivery). Thus, we compared determinants of indirect 11β-HSD2 tissue activity with its direct enzymatic turnover rate in placental samples from spontan

SUBMITTER: Huebner H 

PROVIDER: S-EPMC7858211 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature