Cardiovascular changes during peanut-induced allergic reactions in human subjects.

ABSTRACT:

Background

Food allergy is the most common cause of anaphylaxis. Changes in posture during acute reactions can trigger fatal outcomes, but the impact of allergic reactions on the cardiovascular system in nonfatal reactions remains poorly understood.

Objective

Our aim was to systematically evaluate changes in cardiovascular function during acute allergic reactions to peanut.

Methods

Participants underwent double-blind placebo-controlled food challenge to peanut as part of a clinical trial. Changes in hemodynamic parameters (heart rate, stroke volume, blood pressure, and peripheral blood flow) and electrocardiogram findings during food challenges were assessed using noninvasive continuous monitoring.

Results

A total of 57 adults (median age 24 years [interquartil

SUBMITTER: Ruiz-Garcia M 

PROVIDER: S-EPMC7858218 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature