Identification of 38 novel loci for systemic lupus erythematosus and genetic heterogeneity between ancestral groups.

ABSTRACT: Systemic lupus erythematosus (SLE), a worldwide autoimmune disease with high heritability, shows differences in prevalence, severity and age of onset among different ancestral groups. Previous genetic studies have focused more on European populations, which appear to be the least affected. Consequently, the genetic variations that underlie the commonalities, differences and treatment options in SLE among ancestral groups have not been well elucidated. To address this, we undertake a genome-wide association study, increasing the sample size of Chinese populations to the level of existing European studies. Thirty-eight novel SLE-associated loci and incomplete sharing of genetic architecture are identified. In addition to the human leukocyte antigen (HLA) region, nine disease loci show clear

SUBMITTER: Wang YF 

PROVIDER: S-EPMC7858632 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature