An Evolutionary Arms Race Between Burkholderia pseudomallei and Host Immune System: What Do We Know?

ABSTRACT: A better understanding of co-evolution between pathogens and hosts holds promise for better prevention and control strategies. This review will explore the interactions between Burkholderia pseudomallei, an environmental and opportunistic pathogen, and the human host immune system. B. pseudomallei causes "Melioidosis," a rapidly fatal tropical infectious disease predicted to affect 165,000 cases annually worldwide, of which 89,000 are fatal. Genetic heterogeneities were reported in both B. pseudomallei and human host population, some of which may, at least in part, contribute to inter-individual differences in disease susceptibility. Here, we review (i) a multi-host-pathogen characteristic of the interaction; (ii) selection pressures acting on B. pseudomallei an

SUBMITTER: Chomkatekaew C 

PROVIDER: S-EPMC7858667 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature