Proceed with Caution: Mouse Deep Digit Flexor Tendon Injury Model.

ABSTRACT: The purpose of this study was to determine the feasibility of using mouse models for translational study of flexor tendon repair and reconstruction.

Methods

Quantitative data detailing the gross anatomy, biomechanical characteristics, and microscopic structure of the deep digit flexor tendon (DDF) of the mouse hindpaw were obtained. Histological characterization of the DDF and the anatomy of the digit in the mouse hindpaw are detailed. Biomechanical testing determined the load-to-failure, stress, elastic modulus, and the site of tendon failure.

Results

In gross anatomy, the origins and insertions of the mouse deep digit flexor tendon are similar to those of the human digit, surrounded by a synovial sheath that is only 1- to 2-cells thick. A neurovascular network runs on each

SUBMITTER: Titan AL 

PROVIDER: S-EPMC7859083 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature