Neutrophil degranulation interconnects over-represented biological processes in atrial fibrillation.

ABSTRACT: Despite our expanding knowledge about the mechanism underlying atrial fibrillation (AF), the interplay between the biological events underlying AF remains incompletely understood. This study aimed to identify the functionally enriched gene-sets in AF and capture their interconnection via pivotal factors, that may drive or be driven by AF. Global abundance of the proteins in the left atrium of AF patients compared to control patients (n = 3/group), and the functionally enriched biological processes in AF were determined by mass-spectrometry and gene set enrichment analysis, respectively. The data were validated in an independent cohort (n = 19-20/group). In AF, the gene-sets of innate immune system, metabolic process, cellular component disassembly and ion homeostasis were up-regulated, whi

SUBMITTER: Kawasaki M 

PROVIDER: S-EPMC7859227 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature