Lateral Hypothalamic GABAergic Neurons Encode and Potentiate Sucrose's Palatability.

ABSTRACT: Sucrose is attractive to most species in the animal kingdom, not only because it induces a sweet taste sensation but also for its positive palatability (i.e., oromotor responses elicited by increasing sucrose concentrations). Although palatability is such an important sensory attribute, it is currently unknown which cell types encode and modulate sucrose's palatability. Studies in mice have shown that activation of GABAergic LHA^Vgat+ neurons evokes voracious eating; however, it is not known whether these neurons would be driving consumption by increasing palatability. Using optrode recordings, we measured sucrose's palatability while VGAT-ChR2 transgenic mice performed a brief access sucrose test. We found that a subpopulation of LHA^Vgat+ neurons encodes palatability

SUBMITTER: Garcia A 

PROVIDER: S-EPMC7859279 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature