Characterization of human T cell receptor repertoire data in eight thymus samples and four related blood samples.

ABSTRACT: T cell receptor (TCR) is a heterodimer consisting of TCRα and TCRβ chains that are generated by somatic recombination of multiple gene segments. Nascent TCR repertoire undergoes thymic selections where non-functional and potentially autoreactive receptors are removed. During the last years, the development of high-throughput sequencing technology has allowed a large scale assessment of TCR repertoire and multiple analysis tools are now also available. In our recent manuscript, Human thymic T cell repertoire is imprinted with strong convergence to shared sequences[1], we show highly overlapping thymic TCR repertoires in unrelated individuals. In the current Data in Brief article, we provide a more detailed characterization of the basic features of these thymic and related peripheral

SUBMITTER: Heikkila N 

PROVIDER: S-EPMC7859292 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature