Construction and validation of an N6-methyladenosine-associated prognostic signature in hepatocellular carcinoma.

ABSTRACT: Hepatocellular carcinoma (HCC) is among the most common types of cancer that threat the public health worldwide. N6-methyladenosine (m6A) RNA methylation is associated with cancer initiation and progression, and is dynamically regulated by m6A RNA methylation-associated genes. However, little is known about the expression status and the prognostic value of m6A-associated genes in HCC. The present study aimed to identify the expression profiling pattern and clinical significance of m6A-associated genes in HCC. Consensus clustering analysis was performed to identify the clusters of HCC with different clinical outcomes. A prognostic signature built by the least absolute shrinkage and selection operator Cox regression model was utilized to discover subtypes associated with different clinical o

SUBMITTER: Zhu P 

PROVIDER: S-EPMC7859476 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature