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Chemokines and chemokine receptors during COVID-19 infection.

ABSTRACT: Chemokines are crucial inflammatory mediators needed during an immune response to clear pathogens. However, their excessive release is the main cause of hyperinflammation. In the recent COVID-19 outbreak, chemokines may be the direct cause of acute respiratory disease syndrome, a major complication leading to death in about 40% of severe cases. Several clinical investigations revealed that chemokines are directly involved in the different stages of SARS-CoV-2 infection. Here, we review the role of chemokines and their receptors in COVID-19 pathogenesis to better understand the disease immunopathology which may aid in developing possible therapeutic targets for the infection.

SUBMITTER: Khalil BA

PROVIDER: S-EPMC7859556 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature

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Chemokines and chemokine receptors during COVID-19 infection.

Khalil Bariaa A BA Elemam Noha Mousaad NM Maghazachi Azzam A AA

Computational and structural biotechnology journal 20210127

Chemokines are crucial inflammatory mediators needed during an immune response to clear pathogens. However, their excessive release is the main cause of hyperinflammation. In the recent COVID-19 outbreak, chemokines may be the direct cause of acute respiratory disease syndrome, a major complication leading to death in about 40% of severe cases. Several clinical investigations revealed that chemokines are directly involved in the different stages of SARS-CoV-2 infection. Here, we review the role ...[more]

PMID: 33558827

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