Epitope mimicry analysis of SARS-COV-2 surface proteins and human lung proteins.

ABSTRACT:

Background

Autoimmune response after the infection of SARS-COV-2 is evident as more cases of Guillain Barre syndrome and Kawasaki disease are diagnosed. In this study, we aim to investigate a possible mechanism of autoimmune lung injury.

Methods

We extracted the peptide sequences of surface proteins of the SARS-COV-2 from the NCBI data protein. We used Blastp to assess the homologous sequences between the human proteins in the UNIPROT database that are associated with respiratory distress. Then, we filtered the homologous sequences to those selectively expressed in the lung and homologous to surface viral proteins. We then assessed the epitope sequences for MHC-I and MHC-II using recommended settings and reference MHC in the IEDB database.

Results

Homeobox protein 2.1

SUBMITTER: Morsy S 

PROVIDER: S-EPMC7859657 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature