A narrative review of acute pancreatitis and its diagnosis, pathogenetic mechanism, and management.

ABSTRACT: Acute pancreatitis (AP) is an inflammatory disease that can progress to severe acute pancreatitis (SAP), which increases the risk of death. AP is characterized by inappropriate activation of trypsinogen, infiltration of inflammatory cells, and destruction of secretory cells. Other contributing factors may include calcium (Ca²⁺) overload, mitochondrial dysfunction, impaired autophagy, and endoplasmic reticulum (ER) stress. In addition, exosomes are also associated with pathophysiological processes of many human diseases and may play a biological role in AP. However, the pathogenic mechanism has not been fully elucidated and needs to be further explored to inform treatment. Recently, the treatment guidelines have changed; minimally invasive therapy is advocated more as the core mu

SUBMITTER: Zheng Z 

PROVIDER: S-EPMC7859757 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature