A narrative review of the roles of the miR-15/107 family in heart disease: lessons and prospects for heart disease.

ABSTRACT: Heart disease is one of the leading causes of morbidity and mortality globally. To reduce morbidity and mortality among patients with heart disease, it is important to identify drug targets and biomarkers for more effective diagnosis, prognosis, and treatment. MicroRNAs (miRNAs) are characterized as a group of endogenous, small non-coding RNAs, which function by directly inhibiting target genes. The miR-15/107 family is a group of evolutionarily conserved miRNAs comprising 10 members that share an identical motif of AGCAGC, which determines overlapping target genes and cooperation in the biological process. Accumulating evidence has demonstrated the predominant dysregulation of the miR-15/107 family in cardiovascular disease, neurodegenerative disease, and cancer. In this review, we summar

SUBMITTER: Zheng M 

PROVIDER: S-EPMC7859774 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature